Synthesis and Biological Evaluation of N–CF 3 Diaryl Amines
Abstract
Herein, we reported a one-pot synthesis of N–CF 3 diarylamines using AgSCF 3 and AgF. This work provides a robust protocol for the efficient trifluoromethylation modification of diarylamines, enabling the concise one-pot synthesis of diarylamines bearing a pharmaceutically privileged N–CF 3 unit while demonstrating excellent functional group tolerance and steric hindrance compatibility. The obtained diaryl N–CF 3 compounds were subjected to biological evaluation, and the results revealed that N–CF 3 derivative 2y exhibits good in vitro anti-lung carcinoma activities.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Volume
- 28
- Issue
- 8
- Pages
- 2620–2624
- Publication date
- 16 February 2026
- Language
- EN