Iron-Catalyzed Stereospecific Heterocycle N-Glycosylation with Glycal Epoxides
Abstract
Stereospecific N-glycosylation of heterocycles with glycal epoxides could readily provide valuable building blocks for drug discovery, but heterocycle N-glycosylation with a pyranose-based glycal epoxide is still difficult using existing methods. We report herein an iron-catalyzed stereospecific heterocycle N-glycosylation method for these glycal epoxides in high yields with low catalyst loadings. This method is functional-group-tolerant and effective for a wide variety of functionalized, complex glycal epoxides and heterocycles.
Fields of Study & Subjects
Carbohydrate Chemistry and Synthesis
Glycosylation and Glycoproteins Research
Chemical Synthesis and Analysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 2859–2864
- Publication date
- 20 February 2026
- Language
- EN