Nazarov Cyclization of Geminal-Benzoyl-Phenyl Allenes in Triflic Acid: A Synthetic Route to Pallidol-like Structures

Organic Letters 2026

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Authors: Oussama Abdelhamid Mammeri, Irina А. Boyarskaya, D. V. Spiridonova, Mariya A. Kryukova, Aleksander V. Vasilyev
DOI: 10.1021/acs.orglett.5c05464
Cited by: 0
References: 49

Abstract

Benzoyl substituted allenes in Brønsted superacid TfOH at room temperature afford Nazarov cyclization products, E-/Z -alkylidene indanones. In TfOH at a higher temperature of 70 °C, allenes bearing geminal benzoyl and phenyl substituents undergo further transformations, yielding fused indano–indanones. The latter have been used as precursors in the stereoselective synthesis of the structural analogue of the natural compound, Pallidol.

Fields of Study & Subjects

Organic and Inorganic Chemical Reactions Organic Chemistry Synthesis Methods Synthesis of Indole Derivatives

Publication details

Journal / source
Organic Letters
Volume
28
Issue
7
Pages
2349–2354
Publication date
11 February 2026
Language
EN