C–H Arylation of Imidazo[1,2- a ]pyridines and Zolimidines Catalyzed by Synergistic Tripalladium Clusters
Abstract
Tripalladium cluster [Pd 3 ] + -1–3 (0.33 mol %) presented superior reactivity in the C–H arylation of imidazo[1,2- a ]pyridines and zolimidines with aryl halides compared to palladium monomers and nanoparticles, affording important imidazole[1,2- a ]pyridine and zolimidine derivatives that featured excellent fluorescent and pharmaceutical properties. This method highlights the low catalyst usage, mild conditions, scale-up practicality, and broad substrate scope. Mechanistic and kinetic analyses indicated that [Pd 3 ] + most likely remained intact throughout this synergistic catalytic process.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Synthesis and Reactivity of Heterocycles
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 8
- Pages
- 2625–2631
- Publication date
- 13 February 2026
- Language
- EN