Rauhut–Currier Reaction-Inspired Intramolecular Cyclization Approach Using DBU to Access Biaryl-Fused Cycloheptatriene Derivatives

Organic Letters 2026

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Authors: Prashant Kumar Sinha, Ravula Shivakumar, Jagadeesh Babu Nanubolu, Surisetti Suresh
DOI: 10.1021/acs.orglett.6c00004
Cited by: 2
References: 67

Abstract

In this paper, an efficient intramolecular DBU-catalyzed Rauhut-Currier reaction has been described to access functionalized biaryl-fused cycloheptatriene derivatives. The method is operationally simple, displays broad substrate compatibility, and consistently delivers the products in good to excellent yields with high diastereoselectivities. The scalability of the process to gram-scale syntheses, combined with facile postsynthetic functionalizations, underscores the flexibility and usefulness of this strategy.

Fields of Study & Subjects

Synthesis and pharmacology of benzodiazepine derivatives Cyclization and Aryne Chemistry Catalytic Alkyne Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
10
Pages
3136–3142
Publication date
2 March 2026
Language
EN