Photocatalytic Copper-Promoted Heptafluoroisopropylation of Arylsulfonium Salts with AgCF(CF 3 ) 2
Abstract
A copper-promoted synthesis of heptafluoroisopropylarenes through visible-light-induced coupling of arylsulfonium salts with AgCF(CF 3 ) 2 is presented. The reaction, conducted at room temperature under 420 nm LED irradiation, efficiently converted different types of arylsulfonium salts to the corresponding heptafluoroisopropylarenes in good yields, taming the light-sensitive silver reagent while exhibiting broad functional group tolerance and excellent chemoselectivity. This protocol was also feasible for the introduction of the CF(CF 3 ) 2 moiety into drug molecules, supplying an advantageous method for late-stage molecular functionalization.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 6
- Pages
- 2148–2153
- Publication date
- 30 January 2026
- Language
- EN