Polycyclic Limonoids as Potential Nrf2 Inducers from Trichilia connaroides

Organic Letters 2026

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Authors: Jiaxin Xu, Yan Zhang, Long Wang, Tao Shen, Dong-Mei Ren, Jian-Min Yue, Xiao-Ning Wang
DOI: 10.1021/acs.orglett.6c00016
Cited by: 1
References: 12

Abstract

An investigation of Trichilia connaroides uncovered connarolides A–D ( 1 – 4, respectively), four limonoids with exceptional multiring systems. Compound 1 showcased a unique 5/8/6/6-fused ring system distinguished by a bicyclo[5.2.1 2,4 ]decane A/B ring framework. Compound 2 featured a 5/8/6/5/6 scaffold incorporating a triply fused furan ring, and a long-conjugated system resulted from 3-deoxygenation. X-ray crystallography established the rare 6/3/6/6/6 ring system of 3 . Moreover, 4 was identified as an antioxidant, conferring cytoprotective activity through Nrf2 activation.

Fields of Study & Subjects

Phytochemical compounds biological activities Plant chemical constituents analysis Beetle Biology and Toxicology Studies

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
2166–2170
Publication date
30 January 2026
Language
EN