Photoredox-Enabled Radical Ring-Opening Fluorosulfonamidation/Fluorosulfonylmethylation of Methylenecyclobutanols

Organic Letters 2026

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Authors: Hui Li, Qi Lin, Xiaoxing Li, Ye-Pu Fu, Ni-Ping Pei, Lele Zhang, Wei Li, Li-Jing Wang
DOI: 10.1021/acs.orglett.6c00017
Cited by: 2
References: 50

Abstract

We report a photoredox strategy for radical-initiated ring-opening fluorosulfonamidation/fluorosulfonylmethylation of methylenecyclobutanols using NFSAP ( N -fluorosulfamoylpyridinium salts) and BMSF (bromomethylsulfonyl fluoride) as the respective radical sources. This approach provides efficient access to FSO 2 CH 2 -/FSO 2 N-functionalized γ,δ-unsaturated carbonyl compounds─both FSO 2 CH 2 -/FSO 2 N and γ,δ-unsaturated carbonyl motifs are useful structural scaffolds─while offering good scalability and broad compatibility with postderivatization reactions.

Fields of Study & Subjects

Radical Photochemical Reactions Fluorine in Organic Chemistry Click Chemistry and Applications

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
8
Pages
2632–2637
Publication date
13 February 2026
Language
EN