Hyperacmoses A–C, Three Seco-Norpolyprenylated Acylphloroglucinols from Hypericum acmosepalum with Lipid-Lowering Activity
Abstract
Hyperacmoses A–C, three seco-norpolyprenylated acylphloroglucinols (PPAPs) ( 1 – 3 ), along with two processors ( 4 and 5 ), were purified from Hypericum acmosepalum . Structurally, compounds 1 and 2 represent the first seco-norPPAP with an unprecedented 5/6/5/6/5 pentacyclic framework, while compound 3 is the first seco-norPPAP with a 5/5/6/6 tetracyclic core. Three rare PPAPs had the same biosynthetic precursor, and Baeyer–Villiger oxidation of this precursor at different positions could finally give different types of PPAPs ( 1 – 3 ). Four compounds ( 1, 2, 4, and 5 ) exhibited a better triglyceride (TG) inhibitory effect than atorvastatin in oleic acid-induced HepG2 cells. The compound with the highest potential, compound 1, could prohibit the expression of lipid synthesis proteins, FASN and ACACA, by targeting ACSS2.
Fields of Study & Subjects
Natural Compound Pharmacology Studies
Bioactive natural compounds
Seaweed-derived Bioactive Compounds
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 7
- Pages
- 2465–2470
- Publication date
- 6 February 2026
- Language
- EN