Pd-Catalyzed Aqueous Buchwald–Hartwig Amination with Amphiphilic Polymer PEG–PVEG

Organic Letters 2026

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Authors: Qiong Chai, Fengming Zhang, Minghang Wang, Meiqi Li, Yong Jian Zhang
DOI: 10.1021/acs.orglett.6c00030
Cited by: 2
References: 48

Abstract

An efficient micellar palladium-catalyzed aqueous Buchwald-Hartwig amination has been developed, enabled by the self-assembly of amphiphilic copolymer polyethylene glycol-polyvinylethylene glycol (PEG-PVEG). Using 0.5 mol % BrettPhos-Pd-G3 as a catalyst, the aqueous amination showed broad a substrate scope, including aryl bromides, aryl chlorides, sterically hindered reaction partners, and amides. The practical utility of this micellar system was demonstrated by the gram-scale synthesis of a key pharmaceutical API intermediate and catalyst recycling.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
7
Pages
2374–2379
Publication date
6 February 2026
Language
EN