Dual Non-C1 Synthon Role of CO 2 in Controlled Electrochemical Defluorination

Organic Letters 2026

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Authors: Yulei Zhao, Zixuan Zhang, Jie Liu, Enbo Liu, Xinye Huang, Wenhao Fan, B. H. Wang, Yangkai Dong, Zhiwei Zhang, Yuan‐Ye Jiang
DOI: 10.1021/acs.orglett.6c00031
Cited by: 1
References: 56

Abstract

The dual role of carbon dioxide (CO 2 ) as a non-C1 synthon in controlled electrochemical defluorination has been exploited to produce monofluorinated or difluorinated products. In defluorination, CO 2 may fulfill two functions. First, serving as an electron–electron transfer mediator, it expedites the initial one-electron reduction. Second, acting as an electrophilic reagent, it reacts with the radical anion, diminishing its reduction potential and consequently facilitating the second one-electron reduction.

Fields of Study & Subjects

Fluorine in Organic Chemistry Inorganic Fluorides and Related Compounds CO2 Reduction Techniques and Catalysts

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
5
Pages
1887–1892
Publication date
26 January 2026
Language
EN