Visible-Light-Induced Carbamoylation for Synthesis of Dibenzo[ b,f ][1,4]oxazepine Carbonyl Amino Acid/Peptide Derivatives
Abstract
Introducing amino acids/peptides onto the heterocycle via photocatalytic methods remains a significant challenge. A novel visible-light-driven carbamoylation approach was first developed, facilitating the efficient synthesis of dibenzo[ b,f ][1,4]oxazepine carbonyl amino acid/peptide derivatives (>40 examples, up to 98% yield) from DHP-tagged amino acids/peptides. This strategy offers mild reaction conditions, easy scale-up, broad substrate compatibility, environmental friendliness, simple operation, and high tolerance to diverse functional groups. In addition, it enables late-stage functionalization of amine-containing drugs/natural products/proteins.
Fields of Study & Subjects
Radical Photochemical Reactions
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 2883–2888
- Publication date
- 18 February 2026
- Language
- EN