Exploring γ-Nitroketones as 1,4-Dicarbonyl Precursors for Annulation to Pyridazines through Interrupted Nef Reaction

Organic Letters 2026

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Authors: Hitesh Kumar Labana, Shubham Tiwari, Ankush Gupta, K. Mukherjee, Guddeangadi N. Gururaja
DOI: 10.1021/acs.orglett.6c00059
Cited by: 3
References: 34

Abstract

A practical approach toward pyridazine synthesis has been realized by exploring an interrupted Nef reaction strategy using a combination of sulfur and hydrazine. The access to pyridazine was accomplished through a challenging 1,4-dicarbonyl intermediate through umpolung of γ-nitro ketones under milder conditions. Sulfur was shown to facilitate access to a 1,4-dicarbonyl equivalent. The presented methodology represents a broadly applicable solution to achieve a challenging 1,4-dicarbonyl intermediate using a precursor.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Phenothiazines and Benzothiazines Synthesis and Activities

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
12
Pages
3689–3694
Publication date
16 March 2026
Language
EN