Copper/Photoredox Dual Catalysis for the Redox-Neutral C(sp 3 )–CF 2 H Cross-Coupling between Benzylic Bromides and Tetracoordinated Difluoromethylborates
Abstract
A copper/photoredox dual-catalytic strategy has been developed for radical–radical C(sp 3 )–CF 2 H cross-coupling between alkyl bromides and readily accessible tetracoordinated difluoromethylborates. In this protocol, visible-light-induced single-electron oxidation of the borates generates difluoromethyl radicals ( • CF 2 H), which are subsequently intercepted by a copper catalyst to forge C(sp 3 )–CF 2 H bonds. This redox-neutral approach proceeds without the need for stoichiometric halogen atom transfer (XAT) reagents, oxidants, or reductants, exhibits broad functional group tolerance, and enables late-stage installation of the pharmaceutically privileged CF 2 H motif into aliphatic frameworks.
Fields of Study & Subjects
Radical Photochemical Reactions
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 6
- Pages
- 2188–2193
- Publication date
- 30 January 2026
- Language
- EN