Stereoselective Synthesis of the Western Fragment of Vancoresmycin

Organic Letters 2026

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Authors: Max Schönenbroicher, Maximilian Seul, Simon Morgenschweis, Florian Heppner, Dirk Menche
DOI: 10.1021/acs.orglett.6c00073
Cited by: 2
References: 43

Abstract

The synthesis of the western fragment of vancoresmycin was accomplished in a highly modular and stereoselective manner. Central to this strategy was a modified Cu-catalyzed β-boration protocol for α,β-unsaturated enones, which enabled convergent construction of complex, densely functionalized polyketide architectures with high stereocontrol. Application to a structurally demanding fragment highlighted its potential as a general tool for 1,3-diol construction. In addition, NMR comparison confirmed the stereochemical assignment of the western part of vancoresmycin.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Organoboron and organosilicon chemistry Synthetic Organic Chemistry Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
6
Pages
2194–2199
Publication date
3 February 2026
Language
EN