Photocatalytic In Situ Media-Promoted Cascade for Direct Synthesis of Long-Chain Aryl Ketones via γ-C(sp 3 )–H Activation

Organic Letters 2026

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Authors: Qiang Wang, Si-hui Qiu, Xiang Zou, Ziyang Huang, Yu-Ying Dai, Pei Liang, Fang-Yue Zhang, Lin-Lin Zheng, Zhang-Long Yu, Xi Chen, Yong-Min LIANG, Xiao-ji WANG
DOI: 10.1021/acs.orglett.6c00074
Cited by: 2
References: 44

Abstract

A novel photocatalytic strategy is described for carbonylative difunctionalization of unactivated γ-C(sp 3 )–H bonds with alkenes. Building on a reductively initiated radical pathway from N–O reagents in combination with a 1,5-hydrogen atom transfer (HAT) process, this approach enables the synthesis of aryl ketones under metal-free conditions, mitigating competitive β-hydride elimination pathways.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
14
Pages
4348–4353
Publication date
20 March 2026
Language
EN