Chemodivergent Accesses to Hetero-Bicyclo[3.3.1]nonenes

Organic Letters 2026

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Authors: Yue Li, Hao Wei, Jiaxi Xu, Zhanhui Yang
DOI: 10.1021/acs.orglett.6c00098
Cited by: 1
References: 34

Abstract

Harnessing sterically controlled and rare-earth-catalyzed chemodivergent (3 + 3) annulations between enamines and Achmatowicz rearrangement products (ARPs), we provide practical methods for efficiently constructing two types of highly functionalized, three-dimensional, and rigid bicyclic scaffolds─7-oxa-2-azabicyclo[3.3.1]non-3-enes and 3-oxabicyclo[3.3.1]non-6-enes. Enantiopure products are also synthesized from readily accessed enantiopure ARPs.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Synthesis and Catalytic Reactions Asymmetric Hydrogenation and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
10
Pages
3161–3166
Publication date
2 March 2026
Language
EN