A General Iron-Photocatalyzed Decarboxylative Arylalkylation of Carboxylic Acids with Activated Alkenes

Organic Letters 2026

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Authors: Yi Li, Shi-Gang Yan, Shuang Wu, Ming Hu, Peiyuan Wang, Jin-Heng Li
DOI: 10.1021/acs.orglett.6c00126
Cited by: 2
References: 57

Abstract

-arylacrylamides with commercially available, structurally diverse carboxylic acids, furnishing various alkylated amides bearing acyclic quaternary stereocenters or cyclic alkylated oxindoles with high chemoselectivity. The protocol is applicable to a wide range of carboxylic acid substrates, encompassing primary, secondary, and tertiary alkyl carboxylic acids, along with structurally complex bioactive carboxylic acids.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
7
Pages
2471–2476
Publication date
11 February 2026
Language
EN