Pyridine Synthesis via [3 + 2 + 1] Oxidative Cyclization of Enamines, Ethyl Tertiary Amines, and Alcohols: Copper-Catalyzed Cascade Multicomponent Poly C(sp 3 )–H Functionalization

Organic Letters 2026

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Authors: Chengli Deng, Jingzhi Cheng, Zijing Bai, Yutong He, Ruimin He, Binghan Du, Wei Shi, Peng Gao
DOI: 10.1021/acs.orglett.6c00130
Cited by: 3
References: 56

Abstract

A copper-catalyzed [3 + 2 + 1] oxidative cyclization to access functionalized pyridines was descripted. Employing ethyl tertiary amine as a C2 source, alcohol as a C1 source, and easily handled enamines, one new C–N bond and two new C–C bonds are sequentially constructed by the effective functionalization of multiple C(sp 3 )–H bonds. Besides the readily available raw materials, mild reaction conditions, broad substrate scope, and effective bond-forming strategy, the present approach offers a viable strategy for preparing functionalized pyridines in future organic synthesis.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Catalytic Alkyne Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
8
Pages
2677–2682
Publication date
13 February 2026
Language
EN