Copper-Catalyzed Intramolecular Carbocyclization/1,2-Migration Reaction of Allenols To Access Substituted 2-Sulfonyl Carbazoles
Abstract
A copper-catalyzed intramolecular cascade carbocyclization/1,2-migration of C-2 indolyl-allenol has been achieved to construct the library of 2-sulfonyl carbazoles, which possess considerable biological significance. This modular protocol is operationally simple, exhibiting a broad substrate scope with consistently high yields. Additionally, gram-scale synthesis, product diversification of 2-sulfonyl carbazoles, and DFT studies of the catalytic cycle have been performed. Overall, this study unfolds a new strategy for the one-pot synthesis of sulfonyl carbazoles, which holds significance in medicinal and material chemistry.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 8
- Pages
- 2693–2698
- Publication date
- 13 February 2026
- Language
- EN