Chiral N , N ′-Dioxide/Magnesium(II)-Catalyzed Enantioselective [3,3]-Sigmatropic Rearrangement of 3-Propargyloxyflavones

Organic Letters 2026

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Authors: Deyang Liu, Cuihua Chu, Yi Li, Zihao Deng, Lili Lin, Xiaoming Feng
DOI: 10.1021/acs.orglett.6c00173
Cited by: 0
References: 54

Abstract

'-dioxide/Mg(II) catalytic system was developed for the efficient promotion of the enantioselective [3,3]-sigmatropic rearrangement of 3-propargyloxyflavones. Diverse allene-containing 3-propargyloxyflavone derivatives were thus obtained in moderate to good yields and excellent ee values. Mechanism investigations revealed that water serves as an accelerator for this transformation, while the C-H···π interaction between the catalyst and the chromone substrates constitutes a rational explanation for chiral recognition.

Fields of Study & Subjects

Asymmetric Synthesis and Catalysis Synthesis of Organic Compounds Organic Chemistry Synthesis Methods

Publication details

Journal / source
Organic Letters
Volume
28
Issue
10
Pages
3185–3190
Publication date
25 February 2026
Language
EN