The Electrochemical Functionalization of N–H Bond on N -Heterocycles with Isocyanides to Synthesize Azole Urea Compounds and Methanimines
Abstract
A selective protocol for the synthesis of azole ureas and diheterocycle substituted methanimines from nitrogenous heterocycles and isocyanides was established under electrochemical reaction conditions. By adjustment of the reaction conditions such as electrode materials and solvents, two different types of heterocyclic derivatives of significant value could be selectively obtained with high yields. The reactions have several advantages such as simple reaction conditions and high chemoselectivity and are suitable for various nitrogenous heterocycles and isocyanides.
Fields of Study & Subjects
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3191–3195
- Publication date
- 27 February 2026
- Language
- EN