Light-Induced PdH-Catalyzed Cross-Dimerization of gem -Difluoroalkenes with Alkenes to Access CF 2 H Motifs
Abstract
The CF 2 H group constitutes a valuable structural motif in medicinal chemistry. Herein, we report an efficient light-induced palladium-catalyzed cross-dimerization of electron-deficient gem -difluoroalkenes with styrene derivatives, enabling hydroalkenylation and hydroalkylation reactions to access diverse α-difluoromethyl products. The photoenhanced hydricity of PdH species facilitates efficient insertion into gem -difluoroalkenes for the generation of α-difluoromethyl palladium species. This palladium intermediate subsequently undergoes alkyl Heck reaction with readily available alkenes without defluorination, affording C(sp 3 )–C(sp 2 ) coupling products with monosubstituted alkenes, or C(sp 3 )–C(sp 3 ) coupling products with 1,1-disubstituted alkenes. This protocol features mild conditions and broad functional group tolerance.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Radical Photochemical Reactions
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 8
- Pages
- 2718–2723
- Publication date
- 18 February 2026
- Language
- EN