Photoinduced Chemoselective Alkane Sulfinylation via Fe/Ni Dual Catalysis

Organic Letters 2026

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Authors: Lifang Wang, Shuyang Liu, Shuyang Liu, Ran Xu, Wenlong He, Hui Zi, Fangyi Qu, Ziyi Xu, Shu-Xin Liu, Shu-Xin Liu, Yunhe Jin
DOI: 10.1021/acs.orglett.6c00221
Cited by: 3
References: 48

Abstract

Sulfoxides occupy a central role in natural products and bioactive molecules, yet their direct construction from simple feedstocks remains challenging. Herein, we report a dual iron/nickel photocatalytic strategy for the selective C(sp 3 )–H sulfoxidation of liquid/gaseous alkanes using industrially abundant aryl sulfonyl chlorides. Broad substrate scope, good functional group tolerance, operational simplicity, high chemoselectivity, scale-up synthesis, and late-stage modification are demonstrated, providing a practical platform for the preparation of high-value sulfur-containing compounds.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
8
Pages
2724–2729
Publication date
13 February 2026
Language
EN