Electrochemistry Enables O-Arylation of Tyrosine with Aminoisoxazoles: Late-Stage Diversification of Peptides and Pharmaceuticals
Abstract
) bonds between tyrosine and electron-deficient heteroaromatics. The method achieves site-specific O-heteroarylation of tyrosine-containing drug derivatives and peptides under mild conditions, providing the general platform for constructing tyrosine-electron-deficient heteroaromatic ether linkages. Mechanistic investigations, which included cyclic voltammetry (CV) and radical inhibition experiments, provide support for the proposed mechanism involving electrochemical generation of radical intermediates followed by radical-radical coupling.
Fields of Study & Subjects
Radical Photochemical Reactions
Chemical Synthesis and Analysis
Click Chemistry and Applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3196–3201
- Publication date
- 2 March 2026
- Language
- EN