Photochemical Synthesis of DNA-Encoded 3 H -Azepines via Skeletal Editing of Nitroarenes
Abstract
We report a skeletal editing strategy based on DNA-encoded nitroarenes for the direct conversion of benzene cores into valuable 3 H -azepine scaffolds. This transformation is efficiently promoted by visible light in the presence of P(O i -Pr) 3, which serves as a reductant to generate reactive nitrene intermediates from the nitro group. Demonstrating broad substrate scope with applicability to pharmaceutical molecules, this protocol offers an efficient and versatile route to DNA-encoded 3 H -azepine derivatives. It thus establishes a robust platform for skeletal diversification in DNA-encoded library synthesis.
Fields of Study & Subjects
Chemical Synthesis and Analysis
Radical Photochemical Reactions
CRISPR and Genetic Engineering
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 2990–2994
- Publication date
- 24 February 2026
- Language
- EN