Uncovering the Reactivity of Direct Photoredox Catalyzed α-C–H Alkylation of Alcohols: A Boron-Free Procedure
Abstract
Alcohol functionalization is an important class of pharmaceutically relevant transformations that have increasingly been achieved through photoredox-hydrogen atom transfer catalysis. Many methods rely on exogenous bond-weakening activators such as boron-based catalysts. Herein, a reported hemiboronic acid catalyst was shown to dynamically interact with alcohols, however, with no effect on the efficiency or stereoselectivity of the α-C-H alkylation of alcohols. A simplified procedure affords products in yields of 18-95% without a boron cocatalyst.
Fields of Study & Subjects
Organoboron and organosilicon chemistry
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 2985–2989
- Publication date
- 24 February 2026
- Language
- EN