Enantioselective Synthesis of Seven-Membered Bridged Biaryls via Pd-Catalyzed Asymmetric Annulative Allylic Alkylation
Abstract
An enantioselective formal [5+2] annulation strategy for the efficient synthesis of seven-membered bridged biaryls is reported through palladium-catalyzed asymmetric annulative allylic alkylation of o -indolizinyl N -sulfonylanilines with ( Z )-butene dicarbonate. This reaction features mild conditions, excellent enantioselectivity, and a broad substrate scope. The potential scalability and late-stage elaboration demonstrate the practicality of this protocol.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Axial and Atropisomeric Chirality Synthesis
Asymmetric Synthesis and Catalysis
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3220–3224
- Publication date
- 26 February 2026
- Language
- EN