Palladium-Catalyzed Synthesis of 2-Sulfenyl Benzofused Heterocycles through Domino Cyclization/Thiolation of gem -Dibromoolefins

Organic Letters 2026

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Authors: Shuaichen Zheng, Shaowen Ling, Yingxian Wu, Fu-ao Liu, Xinjin Li, Hui Liu, Lu Zhang, Feng-Gang Sun
DOI: 10.1021/acs.orglett.6c00274
Cited by: 1
References: 76

Abstract

Herein, we describe a straightforward, thiol-free palladium-catalyzed umpolung protocol that uses mild conditions to stitch together readily available dibromoolefins and disulfides, yielding a diverse array of 2-sulfenyl benzofused heterocycles. Upon insertion of Zn into disulfide, in situ generated zinc thiolate engaged in a tandem cyclization/functionalization squence as a viable thiolation agent. In contrast to the existing methods that rely on sophisticated manipulations to prepare starting materials, this technique features high efficiency, synthesis simplicity, commercial availability of reagents, and a broad substrate scope.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
9
Pages
3012–3018
Publication date
24 February 2026
Language
EN