Spectaterpenoids A–G, Sesterterpenoids with Unprecedented Polycyclic Ring System from Aspergillus spectabilis

Organic Letters 2026

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Authors: Mengsha Wei, Yongqi Li, Guiying Xin, Yu Chen, Jieru Guo, Weiguang Sun, Benhong Zhou, Chunmei Chen, Qin Li, Yonghui Zhang, Hucheng Zhu
DOI: 10.1021/acs.orglett.6c00284
Cited by: 2
References: 37

Abstract

Spectaterpenoids A–G ( 1 – 7 ), seven novel sesterterpenoids with five distinct skeleton types, along with one known analogue ( 8 ), were characterized from Aspergillus spectabilis . Notably, compound 1 was a nitrogenous sesterterpenoid possessing an unprecedented 5/3/8/6/5-fused pentacyclic system, while compounds 2 and 3 feature a novel 5/5/8/6/6/5-fused hexacyclic scaffold. Compounds 4 and 5 represent the first examples possessing a five-membered lactam bridge connecting C-5 and C-20 in variecolin derivatives. Plausible biosynthetic pathways for 1 – 8 were proposed.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Fungal Biology and Applications Magnolia and Illicium research

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
11
Pages
3399–3405
Publication date
6 March 2026
Language
EN