Visible-Light-Induced Lactone-Fused Indoline Construction via Radical Dearomatization of Indoles with Alcohols

Organic Letters 2026

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Authors: Jingshan Ai, Qihang Xu, Yaru Liu, Yongcan Liu, Yuchen Teng, Wengang Xu, Qiao Zhang, Mingbo Wu
DOI: 10.1021/acs.orglett.6c00303
Cited by: 0
References: 34

Abstract

We report a visible-light-induced strategy for synthesizing lactone-fused indolines via the radical dearomatization of indoles with simple alcohols. This method combines hydrogen atom transfer (HAT) catalysis and Lewis acid activation operating under ambient conditions. The protocol exhibits a broad substrate scope and excellent diastereoselectivity, leveraging readily available alcohols as alkyl radical precursors. This sustainable approach provides efficient access to complex heterocyclic scaffolds commonly found in bioactive natural products.

Fields of Study & Subjects

Radical Photochemical Reactions Synthesis of Indole Derivatives Sulfur-Based Synthesis Techniques

Publication details

Journal / source
Organic Letters
Volume
28
Issue
7
Pages
2524–2528
Publication date
9 February 2026
Language
EN