Synthesis of Polycyclic Indolines via Spiroindolenines: Mechanistic Validation and HDAC6 Inhibition Potential
Abstract
A highly selective and acid-controlled method for the synthesis of functionalized pentacyclic indolines from tryptophols and o -aminobenzaldehydes is described. Preliminary mechanistic studies provide direct evidence of the involvement of a spiroindolenine intermediate. Furthermore, computational evaluation reveals the products’ strong binding affinity and conformational stability against HDAC6, suggesting their attractive pharmacological profile as promising lead candidates worthy of further investigation.
Fields of Study & Subjects
Histone Deacetylase Inhibitors Research
Catalytic C–H Functionalization Methods
Synthesis and pharmacology of benzodiazepine derivatives
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 3073–3078
- Publication date
- 19 February 2026
- Language
- EN