Two-Step Strategy to Design Organo-Fluorophore: Engaging Palladium Catalysis for Carbo-Oxygenative Cyclization of Chloroprene Derivatives

Organic Letters 2026

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Authors: Puja Singh, Sanjay S. Bisht, Manoj V. Mane, Jonaid Ahmad Malik, Manwi Shankar, Boddu S. Naidu, Javed N. Agrewala, Aslam C. Shaikh
DOI: 10.1021/acs.orglett.6c00322
Cited by: 1
References: 33

Abstract

Herein, we present a two-step protocol for the synthesis of an organo-fluorophore using palladium-catalyzed carbo-oxygenative cyclization of chloroprene derivatives. Protocol is well-tolerated with a broad substrate scope and is feasible at gram-scale synthesis. Mechanistic studies were conducted using H 2 O 18 labeling and density functional theory (DFT) analysis. Notably, organofluorophores show strong photoluminescence and fluorescence lifetimes along with notable redox potential. Furthermore, cell viability studies showed low toxicity and high selectivity for lysosomes, making them promising candidates for green lysotracker imaging agents.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions Radical Photochemical Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
15
Pages
4656–4662
Publication date
1 April 2026
Language
EN