Au(I)/Au(III)-Catalyzed Annulative Addition of Alkynes to Aryl Iodides
Abstract
We present a ligand-enabled, gold-catalyzed syn -1,2-carbohetero-functionalization of both internal and terminal alkynes with o -iodo-arylamides. The transformation integrates a tandem oxidative addition and syn -auration, affording a diverse array of syn -carbohetero-functionalization products in yields of up to 95%. Distinct from the anti -addition typically observed in intermolecular gold catalysis, the involvement of intramolecular annulative cyclization dictates a selective syn -addition pathway. Leveraging Au(I)/Au(III) redox catalysis, this strategy establishes a distinct cyclization strategy that exhibits excellent functional-group tolerance and enables late-stage modification of complex pharmaceutical scaffolds.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3266–3271
- Publication date
- 26 February 2026
- Language
- EN