Markovnikov-Selective Hydroboration of Unactivated Alkenes via MHAT under Cobalt/Photoredox Dual Catalysis

Organic Letters 2026 Open access

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Authors: Yusuke Seino, Shintaro Dozen, Tatsuhiko Yoshino, Kosuke Higashida, Shigeki Matsunaga
DOI: 10.1021/acs.orglett.6c00348
Cited by: 2
References: 67

Abstract

Catalytic Markovnikov-selective hydroboration of unactivated alkenes is a powerful tool for accessing alkyl boronic esters. Here, we report Markovnikov-selective MHAT hydroboration of unactivated alkenes enabled by cobalt/photoredox dual catalysis. The reaction proceeded via radical intermediates, providing high regioselectivity with mono-, di-, and trisubstituted alkenes.

Fields of Study & Subjects

Radical Photochemical Reactions Organoboron and organosilicon chemistry Catalytic C–H Functionalization Methods

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
8
Pages
2771–2776
Publication date
15 February 2026
Language
EN