Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent

Organic Letters 2026 Open access

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Authors: Priyanka Kushwaha, Marvin Mantel, Peter Talbiersky, Yongfu Li, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio
DOI: 10.1021/acs.orglett.6c00353
Cited by: 2
References: 31

Abstract

Liquid-phase peptide synthesis (LPPS) continues to evolve toward more sustainable and efficient methodologies. In this study, we introduce Cyclover as a tag that enables efficient, tunable LPPS in 2Me-THF using propylphosphonic anhydride (T3P®) as a coupling reagent. The extraction protocol reduces the PMI ∼2.7-fold while maintaining high purity and isolated yield, offering a greener and versatile route to complex peptides.

Fields of Study & Subjects

Chemical Synthesis and Analysis Biochemical and Structural Characterization Click Chemistry and Applications

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
9
Pages
3046–3051
Publication date
24 February 2026
Language
EN