Photocatalyzed Site-Selective Formal β-C(sp 3 )–H Sulfonylation of Ketones with Sulfinates
Abstract
)-H sulfonylation of ketones. This method operates under mild conditions and exhibits broad functional group compatibility. Its utility is demonstrated through scalable synthesis and the late-stage functionalization of complex molecules. Mechanistic investigations suggest a reaction pathway involving a photoinduced hydrogen atom transfer (HAT) step, followed by copper-mediated reductive elimination. This protocol provides a direct route to valuable β-sulfonyl ketones from readily available starting materials and inexpensive reagents.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Radical Photochemical Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 8
- Pages
- 2777–2782
- Publication date
- 16 February 2026
- Language
- EN