Highly Regioselective Functionalization of Triborane (L·B 3 H 7 ) through Copper-Catalyzed B–H Bond Insertion Reaction of Tosylhydrazone Compounds
Abstract
A highly regioselective copper-catalyzed B–H bond insertion of triboranes with tosylhydrazones provides diverse organoboron compounds. This method exhibits a broad substrate scope and excellent functional-group compatibility under mild conditions. The reaction is highly selective for the B(2) position, and the resulting B(2)-substituted products can undergo further insertion to yield B(2,3)-disubstituted triboranes. Furthermore, this strategy offers a practical pathway for synthesizing 10 B-labeled agents for boron neutron capture therapy (BNCT).
Fields of Study & Subjects
Boron Compounds in Chemistry
Organoboron and organosilicon chemistry
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 10
- Pages
- 3281–3286
- Publication date
- 3 March 2026
- Language
- EN