HMPA-Enabled Direct γ′-Arylation of Cyclic Vinylogous Esters
Abstract
High Resolution Image Download MS PowerPoint Slide Controlling regioselectivity in deprotonative arylation of conjugated carbonyl systems remains a longstanding challenge. We report a Pd-catalyzed γ′-arylation of cyclic vinylogous esters (CVEs), enabled by Pd(dba) 2 /cataCXium A and hexamethylphosphoramide (HMPA) as a regioselectivity-governing additive. The method accommodates a broad range of (hetero)aryl bromides and CVE substrates. The resulting γ′-aryl CVEs were further converted to α-arylcycloalkenones via Stork–Danheiser transposition.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 7
- Pages
- 2534–2539
- Publication date
- 5 February 2026
- Language
- EN