Direct Access to SCF 3 -Substituted 2H-Thiopyrans Via a [4 + 2] Annulation with 1,3-Dienes, AgSCF 3 , and KI

Organic Letters 2026

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Authors: Kang Guo, Bin Chen, Yongchao Lu, Jiayi Shang, Fang-Fang Xu
DOI: 10.1021/acs.orglett.6c00389
Cited by: 0
References: 32

Abstract

A [4 + 2] annulation with 1,3-dienes, AgSCF 3, and KI has been established, affording a variety of CF 3 S-substituted 2H-thiopyrans with high chemo- and regioselectivities. The intermediate (CF 3 S) 2 C═S is generated in situ via the reaction of AgSCF 3 with KI under mild conditions. This method features the advantages of readily available starting materials, broad substrate scope, operational simplicity, and high atom economy.

Fields of Study & Subjects

Sulfur-Based Synthesis Techniques Synthesis and Reactivity of Sulfur-Containing Compounds Synthesis of heterocyclic compounds

Publication details

Journal / source
Organic Letters
Volume
28
Issue
10
Pages
3293–3297
Publication date
26 February 2026
Language
EN