Bismuth-Catalyzed Photoinduced Ligand-to-Metal Charge Transfer (LMCT) Hydrodecarbonylation of Aldehydes
Abstract
Herein, we disclose a visible-light, bismuth-catalyzed strategy for the hydrodecarbonylation of aliphatic aldehydes. Mechanistic studies highlight chlorine radical formation via Ligand-to-Metal Charge Transfer (LMCT) from in situ generated Bi III Cl 5 2– . After C(sp 2 )–H abstraction by the chlorine radical, decarbonylation followed by Hydrogen Atom Transfer (HAT) furnishes the desired products. Deuterium-labeling studies confirm that water serves as the hydrogen source. The reaction demonstrates excellent functional-group tolerance, including substrates bearing complex, drug-like motifs.
Fields of Study & Subjects
Radical Photochemical Reactions
Asymmetric Hydrogenation and Catalysis
Catalytic C–H Functionalization Methods
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 3057–3062
- Publication date
- 25 February 2026
- Language
- EN