Accessing CF 3 -Cyclopropenes ─ A Platform for the Synthesis of Trifluoromethylated Building Blocks
Abstract
Cyclopropenes are the smallest unsaturated carbocycles. They possess exceptionally high ring strain, resulting in unique reactivity, enabling C═C bond functionalization and ring-opening transformations. Herein, we report a copper-mediated trifluoromethylation of cyclopropenyl benziodoxole (CpBX) reagents, providing access to previously inaccessible, yet highly useful, sp 2 -trifluoromethylated cyclopropenes. Subsequent functionalizations of these novel strained ring building blocks enable access to highly substituted trifluoromethylated cyclopropanes, difluoromethylene cyclopropanes and noncyclic trifluoromethylated compounds.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Cyclopropane Reaction Mechanisms
Synthesis and Reactivity of Heterocycles
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 12
- Pages
- 3730–3735
- Publication date
- 18 March 2026
- Language
- EN