Imidazolidine-Pyrroloimidazolone Pyridine-Cu(OTf) 2 Complex Catalyzed Asymmetric Radical Carbo-Esterification
Abstract
Highly enantioselective radical carbo-esterification of iodoacetic acid with alkenes was achieved under mild conditions with 5 mol % of a chiral copper complex as the catalyst. With Cu(OTf) 2 as Lewis acid and C 1 -symmetric imidazolidine-pyrroloimidazolone pyridine as the ligand, various chiral γ-butyrolactones were obtained in good yields (up to 99% yield) and high enantioselectivities (up to 97% ee). Chiral γ-butyrolactones can be efficiently converted into key chiral building blocks with high enantioselectivity via ring-opening amination and are applicable to the synthesis of antidepressant drugs and other bioactive molecules.
Fields of Study & Subjects
Asymmetric Synthesis and Catalysis
Radical Photochemical Reactions
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Organic Letters
- Volume
- 28
- Issue
- 10
- Pages
- 3315–3320
- Publication date
- 27 February 2026
- Language
- EN