Temperature-Controlled Switchable Cascade Reactions of Alkyne-Tethered Ketoximes and Cyanobenziodoxolone for Divergent Synthesis Cyano-Featured Isoxazolines and 3 H -Pyrrol-3-ones

Organic Letters 2026

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Authors: Wen-Jun Han, Jing-Yi Li, Fang-Long Yang, Lu Li, Gaowei Li, Jun‐Long Zhan, Ya Chen, Jia-Lin Ma, Cai-Jin Liu, Xingyu Zhang, Ning-Ning Cao, Xian-Liang Si
+1 more Lantao Liu
DOI: 10.1021/acs.orglett.6c00433
Cited by: 1
References: 50

Abstract

Herein, we report a divergent radical cascade reaction of alkyne-tethered ketoximes with a cyanobenziodoxolone (CBX) reagent. Simply by modulating the reaction temperature, this process enables switchable and efficient access to a series of structurally valuable cyano-substituted isoxazolines and 3 H -pyrrol-3-ones. Notably, this protocol is characterized by low catalyst loading, broad substrate scope, and operational simplicity. Furthermore, the cyano-containing isoxazolines were obtained with excellent Z -selectivity.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Radical Photochemical Reactions Synthesis and Characterization of Pyrroles

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
10
Pages
3325–3330
Publication date
2 March 2026
Language
EN