Cobalt-Catalyzed Asymmetric Hydroboration of Alkenyl Acetals
Abstract
Transition-metal-catalyzed asymmetric hydroboration of alkenes has emerged as a powerful tool for constructing chiral boronates, yet asymmetric hydroboration of functionalized alkenes remains underdeveloped. Herein, we report a cobalt-catalyzed asymmetric hydroboration of alkenyl acetals, enabling efficient access to enantioenriched boryl acetals (up to 99% ee). The reaction proceeds efficiently on a gram scale with only 1 mol % catalyst and enables diverse downstream functionalizations, highlighting the synthetic potential of the resulting boryl acetals.
Fields of Study & Subjects
Organoboron and organosilicon chemistry
Catalytic C–H Functionalization Methods
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 12
- Pages
- 3747–3752
- Publication date
- 16 March 2026
- Language
- EN