Light-Induced Copper-Catalyzed Arylamination of 1,3-Butadiene

Organic Letters 2026

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Authors: Sijia Li, Hang Luo, Lei Gao, Qiwen Lin, Shizhao Xu, Xiaodong Ma, Luqing Lin
DOI: 10.1021/acs.orglett.6c00447
Cited by: 3
References: 34

Abstract

Here we report a visible-light-driven copper-catalyzed arylamination of 1,3-butadiene using aryl iodides and amines. This method provides allylic amines in good yields with good chemo- and regioselectivity, as well as broad functional group tolerance. Mechanistic investigations indicate that the reaction proceeds via a copper-based catalytic cycle, accompanied by a radical chain pathway that contributes to the formation of the allylic amine products as a parallel process.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
9
Pages
3079–3083
Publication date
23 February 2026
Language
EN