Sulfonium Salt-Mediated Regio- and Stereoselective Aminosulfonylation of Alkynes with Sulfinates and Azoles
Abstract
In this study, a practical and efficient one-pot sulfonium salt-mediated regio- and stereoselective aminosulfonylation of alkynes with sulfinates and azoles has been established. This method enables the synthesis of structurally diverse N-heterocycle-containing ( Z )-vinyl sulfones, featuring a broad substrate scope and excellent functional group tolerance. Notably, gram-scale synthesis, product derivatization, and late-stage functionalization further validate the synthetic utility of this protocol, thereby rendering it highly valuable for applications in organic synthesis and medicinal chemistry.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Click Chemistry and Applications
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 14
- Pages
- 4378–4383
- Publication date
- 27 March 2026
- Language
- EN