Palladium-Catalyzed Annulation of Acyl Saccharins with Norbornene via CO Shuttling

Organic Letters 2026

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Authors: Avinash D. Rokade, Nikhil M. Teke, Kishor L. Handore
DOI: 10.1021/acs.orglett.6c00450
Cited by: 2
References: 47

Abstract

Palladium-catalyzed annulation presents a new approach for synthesizing indanones from readily available N -acyl saccharins and bicyclic alkenes with high yields. This reaction proceeds via cleavage of the C–H, C–C, and C–N bonds of the acyl saccharin and the rearrangement of the carbonyl moiety by decarbonylation and CO reinsertion. This transformation introduces an innovative bond disconnection strategy for annulation reactions via CO shuttling. Additionally, it can also be applied in the synthesis of the CDC7 inhibitor and ferrocene indanone.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Organometallic Complex Synthesis and Catalysis

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
13
Pages
4008–4013
Publication date
20 March 2026
Language
EN