Photocatalytic 1,2,3-Trifunctionalization of β,γ-Unsaturated Ketones via 1,2-Carbonyl Migration to Access Functionalized Indanones

Organic Letters 2026

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Authors: Shi-Gang Yan, Yi Li, Shuang Wu, Ming Hu, Peiyuan Wang, Jin-Heng Li
DOI: 10.1021/acs.orglett.6c00457
Cited by: 4
References: 62

Abstract

Rearrangement reactions are powerful tools in organic synthesis for the construction of new organic molecular scaffolds. Herein we report a photocatalytic radical-mediated 1,2-carbonyl migration of β,γ-unsaturated ketones with α-carbonyl alkyl bromides, producing a wide range of valuable functionalized indanones. This transformation involves a sequential process of alkyl radical generation, radical addition, 1,2-carbonyl rearrangement, annulation, and deprotonation in a single step.

Fields of Study & Subjects

Radical Photochemical Reactions Catalytic C–H Functionalization Methods Synthesis and Characterization of Pyrroles

Publication details

Journal / source
Organic Letters
Publisher
American Chemical Society (ACS)
Volume
28
Issue
9
Pages
3084–3089
Publication date
24 February 2026
Language
EN