Construction of C–S and C–Se Bonds via Deaminative Coupling of Primary Amines
Abstract
Herein, we report a versatile and efficient transition-metal-free protocol for the deaminative functionalization of primary alkyl and aryl amines, enabling the construction of sulfides, selenides, alkynes, alkenes, and oxime esters. This method exhibits excellent functional-group tolerance, a broad substrate scope, and scalability to gram quantities, rendering it highly attractive for the practical synthesis of organosulfur and organoselenium compounds.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Organoselenium and organotellurium chemistry
Advanced Synthetic Organic Chemistry
Publication details
- Journal / source
- Organic Letters
- Publisher
- American Chemical Society (ACS)
- Volume
- 28
- Issue
- 9
- Pages
- 3090–3095
- Publication date
- 25 February 2026
- Language
- EN